Acute Neurological Involvement in Diarrhea-Associated Hemolytic Uremic Syndrome

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Acute neurological involvement in diarrhea-associated hemolytic uremic syndrome.

BACKGROUND AND OBJECTIVES Neurologic involvement is the most threatening complication of diarrhea-associated hemolytic uremic syndrome (D+HUS). DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS We report a retrospective multicenter series of 52 patients with severe initial neurologic involvement that occurred in the course of D+HUS. RESULTS Verotoxigenic Escherichia coli infection was documente...

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Eculizumab in Typical Hemolytic Uremic Syndrome (HUS) With Neurological Involvement

In typical hemolytic uremic syndrome (HUS) approximately 25% of patients show central nervous system (CNS) involvement often leading to serious long-term disabilities. We used the C5-complement inhibitor Eculizumab as rescue therapy. From 2011 to 2014, 11 children (median age 22 months, range 11-175) with enterohemorrhagic Escherichia coli-positive HUS requiring dialysis who had seizures (11/11...

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Interventions for preventing diarrhea-associated hemolytic uremic syndrome: systematic review

BACKGROUND Hemolytic Uremic Syndrome (HUS) may follow infection with Shiga-toxin-producing organisms, principally E. coli O157: H7 (STEC), causing high morbidity and mortality. Our aim was to identify interventions to prevent diarrhea-associated HUS. METHODS Systematic search of the literature for relevant systematic reviews (SRs), randomised controlled trials (RCTs) and public health guideli...

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Recurrence of diabetes after diarrhea-associated hemolytic uremic syndrome.

suscitation then treated in the intensive care unit. Her plasma glucose level was 56.3 mmol/l (1,013 mg/dl) and HbA1c was 6.5%. Serum and urinary C-peptide levels were very low (0.2 ng/ml and 3 g/ day, respectively). There was no increase in C-peptide following intravenous administration of 1 mg glucagon. She had no islet-associated autoantibodies (GAD antibody, islet cell antibody, or insulino...

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Skin involvement in atypical hemolytic uremic syndrome.

Skin involvement in atypical hemolytic uremic syndrome (aHUS) is very uncommon and therefore often unrecognized as a specific symptom of aHUS. We describe 3 cases of patients with aHUS who developed skin lesions that completely recovered when disease-specific treatment was established. These cases suggest that in individuals with aHUS, when skin lesions of unknown origin occur, the possibility ...

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ژورنال

عنوان ژورنال: Clinical Journal of the American Society of Nephrology

سال: 2010

ISSN: 1555-9041,1555-905X

DOI: 10.2215/cjn.08921209